New T-Cell Therapies for Brain Metastasis, CD133 in the Driver's Seat-Reference-Cited by-同舟云学术

New T-Cell Therapies for Brain Metastasis, CD133 in the Driver's Seat

Published:2023-12-01 Issue:3 Volume:30 Page:477-479
ISSN:1078-0432
Container-title:Clinical Cancer Research
language:en
Short-container-title:

Author:

Sloan Anthony R.¹²^ORCID,Thapliyal Mihika¹³^ORCID,Lathia Justin D.¹²³⁴^ORCID

Affiliation:

1. 1Department of Cardiovascular and Metabolic Sciences, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio.

2. 2Case Comprehensive Cancer Center, Cleveland, Ohio.

3. 3Cleveland Clinic Lerner College of Medicine of Case Western Reserve University, Cleveland, Ohio.

4. 4Rose Ella Burkhardt Brain Tumor and Neuro-Oncology Center, Cleveland Clinic, Cleveland, Ohio.

Abstract

Summary Chimeric antigen receptor (CAR)-T cell immunotherapy has revolutionized cancer therapy for some advanced cancers, but success is predicated on identifying the correct cell surface target. In a recent article, the authors leveraged the cancer stem cell surface antigen CD133 to develop a CAR-T therapy for brain metastasis. See related article by Kieliszek et al., p. 554

Funder

Lerner Research Institute, Cleveland Clinic

Case Comprehensive Cancer Center, Case Western Reserve University

National Institutes of Health

Publisher

American Association for Cancer Research (AACR)

Subject

Cancer Research,Oncology

Link

https://aacrjournals.org/clincancerres/article-pdf/doi/10.1158/1078-0432.CCR-23-3051/3388057/ccr-23-3051.pdf

Reference17 articles.

1. Intratumoral delivery of chimeric antigen receptor-T cells targeting CD133 effectively treats brain metastases;Kieliszek;Clin Cancer Res,2024

2. Cancer stem cells in glioblastoma;Lathia;Genes Dev,2015

3. The adaptive transition of glioblastoma stem cells and its implications on treatments;Wang;Signal Transduct Target Ther,2021

4. Targeting cancer stemness in the clinic: from hype to hope;Saygin;Cell Stem Cell,2019

5. Identification of human brain tumour initiating cells;Singh;Nature,2004