Abstract
Tissues with defined cellular hierarchies in development and homeostasis give rise to tumors with cellular hierarchies, suggesting that tumors recapitulate specific tissues and mimic their origins. Glioblastoma (GBM) is the most prevalent and malignant primary brain tumor and contains self-renewing, tumorigenic cancer stem cells (CSCs) that contribute to tumor initiation and therapeutic resistance. As normal stem and progenitor cells participate in tissue development and repair, these developmental programs re-emerge in CSCs to support the development and progressive growth of tumors. Elucidation of the molecular mechanisms that govern CSCs has informed the development of novel targeted therapeutics for GBM and other brain cancers. CSCs are not self-autonomous units; rather, they function within an ecological system, both actively remodeling the microenvironment and receiving critical maintenance cues from their niches. To fulfill the future goal of developing novel therapies to collapse CSC dynamics, drawing parallels to other normal and pathological states that are highly interactive with their microenvironments and that use developmental signaling pathways will be beneficial.
Funder
National Institutes of Health
Sontag Foundation
Cleveland Clinic
James S. McDonnell Foundation
Canadian Institutes of Health Research
Lerner Research Institute
Case Comprehensive Cancer Center
Voices Against Brain Cancer
Blast GBM
Ohio Cancer Research Associates
American Cancer Society
V Foundation for Cancer Research
Publisher
Cold Spring Harbor Laboratory
Subject
Developmental Biology,Genetics
Cited by
1303 articles.
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