A Phase I and Pharmacokinetic Study of VNP40101M, a Novel Sulfonylhydrazine Alkylating Agent, in Patients with Refractory Leukemia-Reference-Cited by-同舟云学术

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A Phase I and Pharmacokinetic Study of VNP40101M, a Novel Sulfonylhydrazine Alkylating Agent, in Patients with Refractory Leukemia

Published:2004-05-01 Issue:9 Volume:10 Page:2908-2917
ISSN:1078-0432
Container-title:Clinical Cancer Research
language:en
Short-container-title:Clin Cancer Res

Author:

Giles Francis,Thomas Deborah,Garcia-Manero Guillermo,Faderl Stefan,Cortes Jorge,Verstovsek Srdan,Ferrajoli Alessandra,Jeha Sima,Beran Miloslav,Koller Charles,Andreeff Michael,Cahill Ann,Clairmont Caroline,Sznol Mario,Kantarjian Hagop

Publisher

American Association for Cancer Research (AACR)

Subject

Cancer Research,Oncology

Cited by 49 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Case Study: Metabolism and Reactions of Alkylating Agents in Cancer Therapy;Drug Metabolism Handbook;2022-11-18

2. pH-dependent general base catalyzed activation rather than isocyanate liberation may explain the superior anticancer efficacy of laromustine compared to related 1,2-bis(methylsulfonyl)-1-(2-chloroethyl)hydrazine prodrugs;Chemical Biology & Drug Design;2017-07-17

3. Biotransformation and Rearrangement of Laromustine;Drug Metabolism and Disposition;2016-06-08

4. Metabolic disposition of the anti-cancer agent [14C]laromustine in male rats;Xenobiotica;2015-03-23

5. Antitumor Sulfonylhydrazines: Design, Structure–Activity Relationships, Resistance Mechanisms, and Strategies for Improving Therapeutic Utility;Journal of Medicinal Chemistry;2015-02-09

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