pH-dependent general base catalyzed activation rather than isocyanate liberation may explain the superior anticancer efficacy of laromustine compared to related 1,2-bis(methylsulfonyl)-1-(2-chloroethyl)hydrazine prodrugs-Reference-Cited by-同舟云学术

pH-dependent general base catalyzed activation rather than isocyanate liberation may explain the superior anticancer efficacy of laromustine compared to related 1,2-bis(methylsulfonyl)-1-(2-chloroethyl)hydrazine prodrugs

Published:2017-07-17 Issue:1 Volume:91 Page:62-74
ISSN:1747-0277
Container-title:Chemical Biology & Drug Design
language:en
Short-container-title:Chem Biol Drug Des

Author:

Penketh Philip G.¹^ORCID,Finch Richard A.²,Sauro Rachel¹,Baumann Raymond P.³,Ratner Elena S.¹,Shyam Krishnamurthy³

Affiliation:

1. Department of Obstetrics; Gynecology & Reproductive Sciences; Yale University School of Medicine; New Haven CT USA

2. Department of Veterinary Sciences; The University of Texas MD Anderson Cancer Center; Bastrop TX USA

3. Department of Pharmacology; Yale University School of Medicine; New Haven CT USA

Funder

Discovery to Cure Program (Yale University)

Center for Strategic Scientific Initiatives, National Cancer Institute

National Foundation for Cancer Research

Publisher

Wiley

Subject

Molecular Medicine,Biochemistry,Drug Discovery,Pharmacology,Organic Chemistry

Link

http://onlinelibrary.wiley.com/wol1/doi/10.1111/cbdd.13057/fullpdf

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5. Synthesis and evaluation of 1-acyl-1,2-bis(methylsulfonyl)-2-(2-chloroethyl)hydrazines as antineoplastic agents

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