GD2 Target Antigen and CAR T Cells: Does It Take More Than Two to Tango?-Reference-Cited by-同舟云学术

GD2 Target Antigen and CAR T Cells: Does It Take More Than Two to Tango?

Published:2024-06-13 Issue:16 Volume:30 Page:3361-3363
ISSN:1078-0432
Container-title:Clinical Cancer Research
language:en
Short-container-title:

Author:

Locatelli Franco¹²^ORCID,Quintarelli Concetta¹³^ORCID

Affiliation:

1. Department of Hematology/Oncology, Cell and Gene Therapy – IRCCS, Bambino Gesù Children’s Hospital, Rome, Italy. 1

2. Department of Life Sciences and Public Health, Catholic University of the Sacred Heart, Rome, Italy. 2

3. Department of Clinical Medicine and Surgery, University of Naples Federico II, Naples, Italy. 3

Abstract

Summary Over the past decade, chimeric antigen receptor T cells have emerged as a breakthrough cancer therapy in selected hematologic malignancies. Translating the success of this therapy to solid tumors is challenging. In this issue, we discuss strategies potentially useful to increase the chimeric antigen receptor T-cell efficacy in this clinical indication. See related article by Fischer-Riepe et al., p. 3564

Publisher

American Association for Cancer Research (AACR)

Link

https://aacrjournals.org/clincancerres/article-pdf/doi/10.1158/1078-0432.CCR-24-0486/3462180/ccr-24-0486.pdf

Reference20 articles.

1. Preclinical development of CAR T cells with antigen-inducible IL-18 enforcement to treat GD2-positive solid cancers;Fischer-Riepe;Clin Cancer Res,2024

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3. Choice of costimulatory domains and of cytokines determines CAR T-cell activity in neuroblastoma;Quintarelli;Oncoimmunology,2018

4. Antitumor activity and long-term fate of chimeric antigen receptor-positive T cells in patients with neuroblastoma;Louis;Blood,2011

5. Antitumor activity without on-target off-tumor toxicity of GD2-chimeric antigen receptor T cells in patients with neuroblastoma;Straathof;Sci Transl Med,2020