Antitumor activity without on-target off-tumor toxicity of GD2–chimeric antigen receptor T cells in patients with neuroblastoma-Reference-Cited by-同舟云学术

Antitumor activity without on-target off-tumor toxicity of GD2–chimeric antigen receptor T cells in patients with neuroblastoma

Published:2020-11-25 Issue:571 Volume:12 Page:
ISSN:1946-6234
Container-title:Science Translational Medicine
language:en
Short-container-title:Sci. Transl. Med.

Author:

Straathof Karin¹²^ORCID,Flutter Barry¹²^ORCID,Wallace Rebecca¹²,Jain Neha²^ORCID,Loka Thalia²^ORCID,Depani Sarita²,Wright Gary²,Thomas Simon³⁴^ORCID,Cheung Gordon Weng-Kit³^ORCID,Gileadi Talia¹^ORCID,Stafford Sian¹^ORCID,Kokalaki Evangelia³^ORCID,Barton Jack¹^ORCID,Marriott Clare²,Rampling Dyanne²^ORCID,Ogunbiyi Olumide²^ORCID,Akarca Ayse U.³,Marafioti Teresa³^ORCID,Inglott Sarah²,Gilmour Kimberly²^ORCID,Al-Hajj Muhammad⁴^ORCID,Day William⁴,McHugh Kieran²^ORCID,Biassoni Lorenzo²^ORCID,Sizer Natalie²^ORCID,Barton Claire⁵,Edwards David⁵,Dragoni Ilaria⁵,Silvester Julie⁵,Dyer Karen⁵^ORCID,Traub Stephanie⁵^ORCID,Elson Lily⁵,Brook Sue⁵,Westwood Nigel⁵^ORCID,Robson Lesley⁵^ORCID,Bedi Ami²,Howe Karen²^ORCID,Barry Ailish²,Duncan Catriona²^ORCID,Barone Giuseppe²^ORCID,Pule Martin³^ORCID,Anderson John¹²^ORCID

Affiliation:

1. Great Ormond Street Hospital for Children NHS Foundation Trust, London WC1N 1EH, UK.

2. Great Ormond Street Hospital for Children NHS Foundation Trust, London WC1N 3JH, UK.

3. UCL Cancer Institute, London WC1E 6DD, UK.

4. Autolus Ltd., London W12 7FP, UK.

5. Centre for Drug Development, Cancer Research UK, London E20 1JQ, UK.

Abstract

Patients with neuroblastoma infused with GD2-directed CAR-T cells experienced immune activation and transient tumor regressions without neurotoxicity.

Funder

Wellcome

Cancer Research UK

Action Medical Research

Great Ormond Street Hospital Charity

Neuroblastoma UK

Research in Childhood Cancer

NIHR Great Ormond Street Biomedical Research Centre

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine