Application of a compact magnetic resonance imaging system for toxicologic pathology: evaluation of lithium-pilocarpine-induced rat brain lesions

Author:

Taketa Yoshikazu1,Shiotani Motohiro1,Tsuru Yoshiharu2,Kotani Sadaharu3,Osada Yoshihide3,Fukushima Tatsuto3,Inomata Akira1,Hosokawa Satoru1

Affiliation:

1. Tsukuba Drug Safety, Global Drug Safety, Biopharmaceutical Assessments Core Function Unit, Eisai Product Creation Systems, Eisai Co., Ltd., 5-1-3 Tokodai, Tsukuba, Ibaraki 300-2635, Japan

2. Research Support Department, Primetech Corp., 1-3-25 Koishikawa, Bunkyo-ku, Tokyo 112-0002, Japan

3. Neuroscience and General Medicine Product Creation Unit, Eisai Product Creation Systems, Eisai Co., Ltd., 5-1-3 Tokodai, Tsukuba, Ibaraki 300-2635, Japan

Publisher

Japanese Society of Toxicologic Pathology

Subject

Toxicology,Pathology and Forensic Medicine

Reference27 articles.

1. 1. Bradley WG. Pathophysiologic correlates of signal alterations. In: Magnetic Sonance in the Central Nervous System. M Brant-Zawadzki (ed). Raven Press, New York. 1986.

2. 2. Johnson GA, Benveniste H, Black RD, Hedlund LW, Maronpot RR, and Smith BR. Histology by magnetic resonance microscopy. Magn Reson Q. 9: 1–30. 1993.

3. 3. Lester DS, Pine PS, Delnomdedieu M, Johannessen JN, and Johnson GA. Virtual neuropathology: three-dimensional visualization of lesions due to toxic insult. Toxicol Pathol. 28: 100–104. 2000.

4. 4. Maronpot RR, Sills RC, and Johnson GA. Applications of magnetic resonance microscopy. Toxicol Pathol. 32(Suppl 2): 42–48. 2004.

5. 5. Morgan B, Horsfield MA, and Steward WP. The role of imaging in the clinical development of antiangiogenic agents. Hematol Oncol Clin North Am. 18: 1183–1206, 2004.

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