Lack of Hepatocarcinogenicity of Combinations of Low Doses of 2-amino-3, 8-dimethylimidazo[4,5-<i>f</i>]quinoxaline and Diethylnitrosamine in Rats: Indication for the Existence of a Threshold for Genotoxic Carcinogens-Reference-Cited by-同舟云学术

Lack of Hepatocarcinogenicity of Combinations of Low Doses of 2-amino-3, 8-dimethylimidazo[4,5-f]quinoxaline and Diethylnitrosamine in Rats: Indication for the Existence of a Threshold for Genotoxic Carcinogens

Published:2012 Issue:3 Volume:25 Page:209-214
ISSN:0914-9198
Container-title:Journal of Toxicologic Pathology
language:en
Short-container-title:J Toxicol Pathol

Author:

Wei Min¹,Kakehashi Anna¹,Yamano Shotaro¹,Tamano Seiko²,Shirai Tomoyuki³,Wanibuchi Hideki¹,Fukushima Shoji¹⁴

Affiliation:

1. Department of Pathology, Osaka City University Graduate School of Medicine, 1-4-3 Asahi-machi, Abeno-ku, Osaka 545-8585, Japan

2. DIMS Institute of Medical Science, Inc., 64 Goura, Nishiazai, Azai-cho, Ichinomiya 491-0113, Japan

3. Department of Experimental Pathology and Tumor Biology, Nagoya City, University Graduate School of Medical Sciences, 1 Kawasumi, Mizuho-cho, Mizuho-ku, Nagoya 467-8601, Japan

4. Japan Bioassay Research Center, 2445 Hirosawa, Hadano, Kanagawa 257-0015, Japan

Publisher

Japanese Society of Toxicologic Pathology

Subject

Toxicology,Pathology and Forensic Medicine

Link

https://www.jstage.jst.go.jp/article/tox/25/3/25_2012-0017/_pdf

Reference21 articles.

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2. 2. Wei M, Wanibuchi H, Nakae D, Tsuda H, Takahashi S, Hirose M, Totsuka Y, Tatematsu M, and Fukushima S. Low-dose carcinogenicity of 2-amino-3-methylimidazo[4,5-f]quinoline in rats: Evidence for the existence of no-effect levels and a mechanism involving p21(Cip/WAF1). Cancer Sci. 102: 88–94. 2011.

3. 3. Sofuni T, Hayashi M, Nohmi T, Matsuoka A, Yamada M, and Kamata E. Semi-quantitative evaluation of genotoxic activity of chemical substances and evidence for a biological threshold of genotoxic activity. Mutat Res. 464: 97–104. 2000.

4. 4. Williams GM, Iatropoulos MJ, and Jeffrey AM. Mechanistic basis for nonlinearities and thresholds in rat liver carcinogenesis by the DNA-reactive carcinogens 2-acetylaminofluorene and diethylnitrosamine. Toxicologic pathology. 28: 388–395. 2000.

5. 5. Waddell WJ, Fukushima S, and Williams GM. Concordance of thresholds for carcinogenicity of N-nitrosodiethylamine. Archives of toxicology. 80: 305–309. 2006.

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