Progression process and safety assessment adaptation of endometrial lesions in ENU-induced 2-stage uterine carcinogenicity in a Tg-rasH2 mouse model-Reference-Cited by-同舟云学术

Progression process and safety assessment adaptation of endometrial lesions in ENU-induced 2-stage uterine carcinogenicity in a Tg-rasH2 mouse model

Published:2018 Issue:1 Volume:31 Page:35-41
ISSN:0914-9198
Container-title:Journal of Toxicologic Pathology
language:en
Short-container-title:J Toxicol Pathol

Author:

Kuroda Hiroyuki¹,Kinomoto Toshiko²,Ogawa Shuji²,Kawabe Mayumi³,Suguro Mayuko³,Naraoka Hitoshi⁴,Takamatsu Kazuhiko⁴,Oishi Yuji⁵

Affiliation:

1. R&D PLANNING, Zeria Pharmaceutical Co., Ltd., 10-11 Nihonbashi Kobuna-cho, Chuo-ku, Tokyo 103-8351, Japan

2. Central Research Laboratories, Zeria Pharmaceutical Co., Ltd., 2512-1 Aza Numagami, Oshikiri, Kumagaya-shi, Saitama 360-0111, Japan

3. DIMS Institute of Medical Science, Inc., 64 Goura, Nishiazai, Azai-cho, Ichinomiya, Aichi 491-0113, Japan

4. Tsukuba Research Center, Astellas Pharma Inc., 21 Miyukigaoka, Tsukuba-shi, Ibaraki 305-8585, Japan

5. Department Molecular Pathology, Osaka City University, 1-4-3 Asahi-machi, Abeno-ku, Osaka-City, Osaka 545-8585, Japan

Publisher

Japanese Society of Toxicologic Pathology

Subject

Toxicology,Pathology and Forensic Medicine

Link

https://www.jstage.jst.go.jp/article/tox/31/1/31_2017-0035/_pdf

Reference17 articles.

1. 1. Kuroda H, Yamaguchi T, Kinomoto T, Ogawa S, Shiga A, Naraoka H, Takamatsu K, and Oishi Y. The concern for uterine carcinogenesis in safety assessments for a new pharmaceutical. Fundam. Toxicol. Sci. 2: 117–126. 2015.

2. 2. Report on the Deliberation Results: Evaluation and Licensing Division, Pharmaceutical and Food Safety Bureau, Ministry of Health, Labour and Welfare: Acofide Tablets 100 mg. 2013, from Pharmaceuticals and Medical Devices Agency website: https://www.pmda.go.jp/files/000153467.pdf

3. 3. Kuroda H, Yamaguchi T, Kinomoto T, Ogawa S, Naraoka H, Takamatsu K, and Oishi Y. A study on the influence of acotiamide hydrochloride hydrate on sex hormones, using a uterotrophic bioassay in rat. Fundam Toxicol Sci. 3: 19–25. 2016.

4. 4. Ando-Lu J, Takahashi M, Imai S, Ishihara R, Kitamura T, Iijima T, Takano S, Nishiyama K, Suzuki K, and Maekawa A. High-yield induction of uterine endometrial adenocarcinomas in Donryu rats by a single intra-uterine administration of N-ethyl-N’-nitro-N-nitrosoguanidine via the vagina. Jpn J Cancer Res. 85: 789–793. 1994.

5. 5. Watanabe T, Kashida Y, Yasuhara K, Koujitani T, Hirose M, and Mitsumori K. Rapid induction of uterine endometrial proliferative lesions in transgenic mice carrying a human prototype c-Ha-ras gene (rasH2 mice) given a single intraperitoneal injection of N-ethyl-N-nitrosourea. Cancer Lett. 188: 39–46. 2002.

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