Phytochemical and Biological investigations of Phoenix paludosa Roxb.

Abstract

Lupeol (1), epilupeol (2) and β-sitosterol (3) were isolated from the n-hexane and the carbontetrachloride soluble fraction of a methanol extract of the leaves of Phoenix paludosa Roxb. The n-hexane, carbontetrachloride and chloroform soluble materials from the concentrated methanol extract were subjected toantimicrobial screening and brine shrimp lethality bioassay. All of the partitionates showed insensitivity to microbialgrowth, while the n-hexane, chloroform and methanol soluble fractions showed significant cytotoxicity having LC502.17 μg/ml, 2.77 μg/ml and 2.46 μg/ml, respectively. This is the first report of isolation of the compounds 1-3 andbioactivities of P. paludosa.Key words: Phoenix paludosa; Aracaceae; Lupeol; Epi-Lupeol; β-sitosterol; Brine shrimp lethality bioassay;Antimicrobial.DOI: 10.3329/dujps.v8i1.5329Dhaka Univ. J. Pharm. Sci. 8(1): 7-10, 2009 (June)