DIAGNOSTIC CHEMORESISTANT MYCOBACTERIUM TUBERCULOSIS IN THE TERNOPIL REGION OF UKRAINE

Abstract

The aim: To analyze the changes in indicators of tuberculosis mycobacteria sensitivity to anti-mycobacterial drugs over the past nine years in Ternopol region (Ukraine) and to develop recommendations for the use of drug combinations in this region. Materials and methods: The medical examinations were carried out in the Clinical and Diagnostic Laboratory of Ternopil Regional Tuberculosis Hospital during 2007-2017. Sensitivity analysis was carried out on a solid Löwenstein-Jensen medium and in liquid Meedlebrook medium using automatic bacteriological BACTEC 1443 tests with addition to the media of first line anti-TB drugs. Results: The sensitivity of Mycobacterium tuberculosis to anti-TB drugs has decreased in 2017 comparing to 2007, both among new cases and relapses of the disease.During this period in newly diagnosed patients the number of M. tuberculosis sensitive to first-line anti-TB drugs has decreased by 6.1%. Conclusions: Considering the increase in multi-resistant pathogens in newly diagnosed and relapsed of tuberculosis cases, it is necessary to use a modern express methods of diagnostics for the causative agents of tuberculosis and to study their sensitivity to antimycobacterial drugs, especially by using molecular genetics methods.