Role of BKCa channels in diabetic vascular complications

Abstract

Objective This review focuses on the role of the large conductance calcium-activated potassium (BKCa) channels in diabetic vascular complications. Data sources Relevant articles published in English or Chinese from 1981 to present were selected from PubMed. The search terms were “BKCa channels” and “diabetes”. Important references from selected articles were also retrieved. Study selection Articles regarding the role of BKCa channels in diabetic vascular complications and relevant mechanisms were selected. Results The BKCa channels are abundantly expressed in vascular smooth cells and play an important role in regulation of vascular tone. Multiple studies indicated that the expression and function of BKCa channels are altered by different mechanisms in diabetic vascular diseases such as coronary arterial disease, cerebral arterial disease, and diabetic retinopathy. Conclusion BKCa channels may play an important role in diabetic vascular complications and may be an effective therapeutic target for relieving and reducing the burden of diabetic vascular complications.