Regulation of RAGE for Attenuating Progression of Diabetic Vascular Complications-Reference-Cited by-同舟云学术

Regulation of RAGE for Attenuating Progression of Diabetic Vascular Complications

Published:2012 Issue: Volume:2012 Page:1-8
ISSN:1687-5214
Container-title:Experimental Diabetes Research
language:en
Short-container-title:Experimental Diabetes Research

Author:

Win Myat Thu Thu¹^ORCID,Yamamoto Yasuhiko¹,Munesue Seiichi¹,Saito Hidehito¹,Han Dong¹,Motoyoshi So¹,Kamal Tarek¹,Ohara Takuro¹,Watanabe Takuo¹,Yamamoto Hiroshi¹

Affiliation:

1. Department of Biochemistry and Molecular Vascular Biology, Kanazawa University Graduate School of Medical Science, Kanazawa 920-8640, Japan

Abstract

Diabetic angiopathy including micro- and macroangiopathy is concerned with high rate of morbidity and mortality in patients with long-standing diabetes. Receptor for advanced glycation end products (RAGE) and its ligands have been considered as important pathogenic triggers for the progression of the vascular injuries in diabetes. The deleterious link between RAGE and diabetic angiopathy has been demonstrated in animal studies. Preventive and therapeutic strategies focusing on RAGE and its ligand axis may be of great importance in relieving diabetic vascular complications and reducing the burden of disease.

Publisher

Hindawi Limited

Subject

General Medicine,Endocrinology, Diabetes and Metabolism

Link

http://downloads.hindawi.com/journals/jdr/2012/894605.pdf

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