In-depth qualitative and quantitative analysis of composite glycosylation profiles and other micro-heterogeneity on intact monoclonal antibodies by high-resolution native mass spectrometry using a modified Orbitrap-Reference-Cited by-同舟云学术

In-depth qualitative and quantitative analysis of composite glycosylation profiles and other micro-heterogeneity on intact monoclonal antibodies by high-resolution native mass spectrometry using a modified Orbitrap

Published:2013-11 Issue:6 Volume:5 Page:917-924
ISSN:1942-0862
Container-title:mAbs
language:en
Short-container-title:mAbs

Author:

Rosati Sara,van den Bremer Ewald TJ,Schuurman Janine,Parren Paul WHI,Kamerling Johannis P,Heck Albert JR

Publisher

Informa UK Limited

Subject

Immunology,Immunology and Allergy

Link

http://www.tandfonline.com/doi/pdf/10.4161/mabs.26282

Reference38 articles.

1. Glycosylation of Recombinant Antibody Therapeutics

2. Terminal sugars of Fc glycans influence antibody effector functions of IgGs

3. The Absence of Fucose but Not the Presence of Galactose or Bisecting N-Acetylglucosamine of Human IgG1 Complex-type Oligosaccharides Shows the Critical Role of Enhancing Antibody-dependent Cellular Cytotoxicity

4. Unique carbohydrate-carbohydrate interactions are required for high affinity binding between Fc RIII and antibodies lacking core fucose

5. Anti-Inflammatory Activity of Immunoglobulin G Resulting from Fc Sialylation

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