Affiliation:
1. Calico Life Sciences LLC. 1170 Veterans Blvd, South San Francisco 94080
2. Ancestry, San Francisco, California 94107, and
3. Ancestry, Lehi, Utah 84043
Abstract
Abstract
We present a massive investigation into the genetic basis of human lifespan. Beginning with a genome-wide association (GWA) study using a de-identified snapshot of the unique AncestryDNA database – more than 300,000 genotyped individuals linked to pedigrees of over 400,000,000 people – we mapped six genome-wide significant loci associated with parental lifespan. We compared these results to a GWA analysis of the traditional lifespan proxy trait, age, and found only one locus, APOE, to be associated with both age and lifespan. By combining the AncestryDNA results with those of an independent UK Biobank dataset, we conducted a meta-analysis of more than 650,000 individuals and identified fifteen parental lifespan-associated loci. Beyond just those significant loci, our genome-wide set of polymorphisms accounts for up to 8% of the variance in human lifespan; this value represents a large fraction of the heritability estimated from phenotypic correlations between relatives.
Publisher
Oxford University Press (OUP)
Subject
Genetics (clinical),Genetics,Molecular Biology
Reference76 articles.
1. Convergence of Evidence from a Methylome-Wide CpG-SNP Association Study and GWAS of Major Depressive Disorder. Translational Psychiatry;Aberg,2018
2. Income inequality and mortality: a multilevel prospective study of 521 248 individuals in 50 US states.;Backlund,2007
3. Ball, C, M Barber, J Byrnes, J Callaway, K Chahine et al., 2013 Ethnicity Estimate White Paper. https://www.ancestry.com/dna/resource/whitePaper/AncestryDNA-Ethnicity-White-Paper.pdf.
4. Ball, C, M Barber, J Byrnes, P Carbonetto, K Chahine et al., 2016 Ancestry DNA Matching White Paper. https://www.ancestry.com/corporate/sites/default/files/AncestryDNA-Matching-White-Paper.pdf.
5. Genome-Wide Linkage Analysis for Human Longevity: Genetics of Healthy Aging Study.;Beekman;Aging Cell,2013
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