Genome Sequence of the Human Opportunistic Fungus Arthrocladium fulminans (CBS 136243)

Author:

Moreno Leandro Ferreira123ORCID,Menezes da Silva Nickolas34ORCID,Weiss Vinicius Almir5ORCID,de Fátima Costa Flavia3,Bittencourt Juliana V6,Macedo Luciano Medina36ORCID,Gomes Renata R5,Souza Emanuel M78ORCID,Vicente Vania Aparecida35,Stielow Benjamin1,de Hoog Sybren1245ORCID

Affiliation:

1. Westerdijk Fungal Biodiversity Institute, Utrecht, The Netherlands

2. Institute of Biodiversity and Ecosystem Dynamics, University of Amsterdam, Amsterdam, Netherlands

3. Graduate Program in Bioprocess Engineering and Biotechnology, Departament of Bioprocess Engineering and Biotechnology, Federal University of Paraná, Curitiba, PR, Brazil

4. Center of Expertise in Mycology Radboudumc / CWZ, Nijmegen, The Netherlands

5. Graduate Program in Microbiology, Parasitology and Pathology, Department of Basic Pathology, Federal University of Paraná State, Curitiba, PR, Brazil

6. Technological Federal University of Paraná, Ponta Grossa, PR, Brazil

7. Department of Biochemistry and Molecular Biology, Federal University of Paraná State, Curitiba, PR, Brazil

8. Departament of Bioinformatics

Abstract

Abstract The black yeast-like fungus Arthrocladium fulminans is known from strains that cause severe and eventually fatal disseminated infections in immunocompromised patients. Given the dramatic outcome of this clinical case, it is essential to understand the virulence potential of this species. The fungus is a member of the family Trichomeriaceae, at some phylogenetic distance from the Herpotrichiellaceae where most infectious fungi in the order Chaetothyriales are located. Main ecological preferences among Trichomeriaceae include colonization of exposed inert surfaces. Currently, black yeasts genomes that are available in public databases cover members of the families Herpotrichiellaceae and Cyphellophoraceae. In the present report, we sequenced the genome of the first member and only clinical representative of the family Trichomeriaceae.

Publisher

Oxford University Press (OUP)

Subject

Genetics (clinical),Genetics,Molecular Biology

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