Genes Important for Schizosaccharomyces pombe Meiosis Identified Through a Functional Genomics Screen

Author:

Blyth Julie1,Makrantoni Vasso1,Barton Rachael E1,Spanos Christos1,Rappsilber Juri12,Marston Adele L1

Affiliation:

1. Wellcome Centre for Cell Biology, Institute of Cell Biology, School of Biological Sciences, University of Edinburgh, EH9 3BF, UK

2. Institute of Biotechnology, Technische Universität Berlin, 13355 Berlin, Germany

Abstract

Abstract Meiosis is a specialized cell division that generates gametes, such as eggs and sperm. Errors in meiosis result in miscarriages and are the leading cause of birth defects; however, the molecular origins of these defects remain unknown. Studies in model organisms are beginning to identify the genes and pathways important for meiosis, but the parts list is still poorly defined. Here we present a comprehensive catalog of genes important for meiosis in the fission yeast, Schizosaccharomyces pombe. Our genome-wide functional screen surveyed all nonessential genes for roles in chromosome segregation and spore formation. Novel genes important at distinct stages of the meiotic chromosome segregation and differentiation program were identified. Preliminary characterization implicated three of these genes in centrosome/spindle pole body, centromere, and cohesion function. Our findings represent a near-complete parts list of genes important for meiosis in fission yeast, providing a valuable resource to advance our molecular understanding of meiosis.

Publisher

Oxford University Press (OUP)

Subject

Genetics

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