Defects Associated with Mitochondrial DNA Damage Can Be Mitigated by Increased Vacuolar pH in Saccharomyces cerevisiae-Reference-Cited by-同舟云学术

Defects Associated with Mitochondrial DNA Damage Can Be Mitigated by Increased Vacuolar pH in Saccharomyces cerevisiae

Published:2013-05-01 Issue:1 Volume:194 Page:285-290
ISSN:1943-2631
Container-title:Genetics
language:en
Short-container-title:

Author:

Garipler Görkem¹,Dunn Cory D¹

Affiliation:

1. Department of Molecular Biology and Genetics, Koç University, Sarıyer, Istanbul, 34450, Turkey

Abstract

Abstract While searching for mutations that alleviate detrimental effects of mitochondrial DNA (mtDNA) damage, we found that disrupting vacuolar biogenesis permitted survival of a sensitized yeast background after mitochondrial genome loss. Furthermore, elevating vacuolar pH increases proliferation after mtDNA deletion and reverses the protein import defect of mitochondria lacking DNA.

Publisher

Oxford University Press (OUP)

Subject

Genetics

Link

https://academic.oup.com/genetics/article-pdf/194/1/285/42185533/genetics0285.pdf

Reference47 articles.

1. Prohibitin family members interact genetically with mitochondrial inheritance components in Saccharomyces cerevisiae.;Berger;Mol. Cell. Biol.,1998

2. Genome-wide analysis reveals the vacuolar pH-stat of Saccharomyces cerevisiae.;Brett;PLoS ONE,2011

3. Induction of petite mutation and inhibition of synthesis of respiratory enzymes in various yeasts.;Bulder;Antonie van Leeuwenhoek,1964

4. The petite mutation in yeasts: 50 years on.;Chen;Int. Rev. Cytol.,2000

5. Kinetic properties of F1-ATPase influence the ability of yeasts to grow in anoxia or absence of mtDNA.;Clark-Walker;Mitochondrion,2003

Cited by 12 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. The metabolic growth limitations of petite cells lacking the mitochondrial genome;Nature Metabolism;2021-11

2. Pharmacological Inhibition of the Vacuolar ATPase in Bloodstream-Form Trypanosoma brucei Rescues Genetic Knockdown of Mitochondrial Gene Expression;Antimicrobial Agents and Chemotherapy;2018-09

3. Reduced Glucose Sensation Can Increase the Fitness of Saccharomyces cerevisiae Lacking Mitochondrial DNA;PLOS ONE;2016-01-11

4. Elongator-dependent modification of cytoplasmic tRNALysUUUis required for mitochondrial function under stress conditions;Nucleic Acids Research;2015-08-03

5. Vacuolar ATPase depletion affects mitochondrial ATPase function, kinetoplast dependency, and drug sensitivity in trypanosomes;Proceedings of the National Academy of Sciences;2015-07-06