Pharmacological Inhibition of the Vacuolar ATPase in Bloodstream-Form Trypanosoma brucei Rescues Genetic Knockdown of Mitochondrial Gene Expression-Reference-Cited by-同舟云学术

Pharmacological Inhibition of the Vacuolar ATPase in Bloodstream-Form Trypanosoma brucei Rescues Genetic Knockdown of Mitochondrial Gene Expression

Published:2018-09 Issue:9 Volume:62 Page:
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Schaffner-Barbero Claudia¹,Miskinyte Migla¹,Grewal Jaspreet Singh²,Schnaufer Achim¹^ORCID

Affiliation:

1. Institute of Immunology & Infection Research, University of Edinburgh, Edinburgh, United Kingdom

2. Department of Biology, Centre for Immunology and Infection, University of York, York, United Kingdom

Abstract

Trypanosomatid parasites cause diseases in humans and livestock. It was reported that partial inhibition of the vacuolar ATPase (V-ATPase) affects the dependence of Trypanosoma brucei on its mitochondrial genome (kinetoplast DNA [kDNA]), a target of the antitrypanosomatid drug isometamidium.

Funder

RCUK | Medical Research Council

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.02268-17

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1. Kinetoplastids: related protozoan pathogens, different diseases

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5. U-Insertion/Deletion mRNA-Editing Holoenzyme: Definition in Sight

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