Interaction Between Eye Pigment Genes and Tau-Induced Neurodegeneration in Drosophila melanogaster-Reference-Cited by-同舟云学术

Interaction Between Eye Pigment Genes and Tau-Induced Neurodegeneration in Drosophila melanogaster

Published:2010-09-01 Issue:1 Volume:186 Page:435-442
ISSN:1943-2631
Container-title:Genetics
language:en
Short-container-title:

Author:

Ambegaokar Surendra S¹,Jackson George R²

Affiliation:

1. Neuroscience Interdepartmental Ph.D. Program, Brain Research Institute, Center for Neurobehavioral Genetics, Semel Institute for Neuroscience and Human Behavior, and Department of Neurology, David Geffen School of Medicine, University of California, Los Angeles, California 90095 and

2. Departments of Neurology, Neuroscience & Cell Biology, and Biochemistry and Molecular Biology, and Mitchell Center for Neurodegenerative Diseases, University of Texas Medical Branch, Galveston, Texas 77555

Abstract

Abstract Null mutations in the genes white and brown, but not scarlet, enhance a rough eye phenotype in a Drosophila melanogaster model of tauopathy; however, adding rosy mutations suppresses these effects. Interaction with nucleotide-derived pigments or increased lysosomal dysregulation are potential mechanisms. Finally, tau toxicity correlates with increased GSK-3β activity, but not with tau phosphorylation at Ser202/Thr205.

Publisher

Oxford University Press (OUP)

Subject

Genetics

Link

https://academic.oup.com/genetics/article-pdf/186/1/435/42178968/genetics0435.pdf

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