A Transcriptional Regulatory Map of Iron Homeostasis Reveals a New Control Circuit for Capsule Formation in Cryptococcus neoformans

Author:

Do Eunsoo1,Cho Yong-Joon2,Kim Donghyeun1,Kronstad James W3,Jung Won Hee1

Affiliation:

1. Department of Systems Biotechnology, Chung-Ang University, Anseong 17546, Korea

2. School of Biological Sciences and Research Institute of Basic Sciences, Seoul National University, Seoul 08826, Korea

3. Michael Smith Laboratories, University of British Columbia, Vancouver, British Columbia V6T 1Z4, Canada

Abstract

Abstract To overcome host iron restriction, the human fungal pathogen Cryptococcus neoformans uses several iron uptake mechanisms to cause disease. In this study....

Publisher

Oxford University Press (OUP)

Subject

Genetics

Reference87 articles.

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2. The second finger of Urbs1 is required for iron-mediated repression of sid1 in Ustilago maydis.;An;Proc. Natl. Acad. Sci. USA,1997

3. The monothiol glutaredoxin Grx4 regulates iron homeostasis and virulence in Cryptococcus neoformans.;Attarian;MBio,2018

4. Role of clathrin-mediated endocytosis in the use of heme and hemoglobin by the fungal pathogen Cryptococcus neoformans.;Bairwa;Cell. Microbiol.,2019

5. Trimmomatic: a flexible trimmer for Illumina sequence data.;Bolger;Bioinformatics,2014

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