Science learning should gives a good scientific process experience and promotes high level thinking skills on students. However, the real conditions show that the both scientific process and integration of high order thinking can’t be been applied well. The solution to this problem is the discovery learning model by integrating virtual laboratory and high order thinking. The objective of the research was to investigate the effects of the application of the discovery learning model by integrating virtual laboratory and high order thinking to improve learning outcomes of students. The type of research is classroom action research with a cycle model. The discovery learning model was applied on grade XI MIA 1 students in SMAN 10 Padang. The instrument for collecting data consisted of written test for knowledge aspect and problem solving skill, observation sheet for attitudes aspect, and performanceassessment sheet for science process skills aspect. The data analysis technique that used were descriptive statistical analysis and correlated comparison test. From the results of data analysis it can be stated that the application of the discovery learning model by integrating virtual laboratory and high order thinking can improve the learning outcomes of students including knowledge, attitudes, science process skills aspect and problem solving skills. Thus, the application of the discovery learningmodel by integrating virtual laboratory and high order thinking has given a positive effect in improvinglearning outcomes of students.