ANTITUMOR DRUG ELLIPTICINE INHIBITS THE ACTIVITIES OF RAT HEPATIC CYTOCHROMES P450
Author:
Publisher
Palacky University Olomouc
Subject
General Biochemistry, Genetics and Molecular Biology,General Medicine
Link
http://biomed.papers.upol.cz/doi/10.5507/bp.2005.076.pdf
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1. The anticancer agent ellipticine on activation by cytochrome P450 forms covalent DNA adducts☆1☆Supported by German Cancer Research Center, Grant Agency of the Czech Republic (grant 203/01/0996) and the Ministry of Education of the Czech Republic (grant MSM 1131 00001).1Abbreviations: α-NF, α-naphthoflavone; 3-IPMDIA, 3-isopropenyl-3-methyldiamantane; CHAPS, 3-[(3-cholamidopropyl)-dimethylammonio]-1-propane sulfonate; CYP, cytochrome P450; IC50, 50% inhibitory dose; MDR, multidrug resistance; PEI, polyethylenimine; RAL, relative adduct labeling; TLC, thin-layer chromatography
2. Attempts to target antitumor drugs towards opioid receptor-rich mouse tumor cells with enkephalinellipticinium conjugates;Rigaudy;Cancer Res,1989
3. Design, Synthesis, and Biological Evaluation of Ellipticine−Estradiol Conjugates
4. Cytotoxic agents directed to peptide hormone receptors: Defining the requirements for a successful drug
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