Microcirculatory changes in patients with chronic obstructive pulmonary disease and arterial hypertension

Abstract

Objective: to study the dynamics of microcirculation indices in patients with arterial hypertension, chronic obstructive pulmonary disease, and in their combination. Material and methods: the study included 226 people, of which 66 people were patients with chronic obstructive pulmonary disease, 54 patients with arterial hypertension, 74 people with a combination of chronic obstructive pulmonary disease and arterial hypertension, 32 relatively healthy volunteers. To assess the circulatory bed, we used a computerized ultrasonic Doppler instrument Minimax-Doppler-K, LLC JV «Minimax». Results: in patients with COPD and AH, microcirculation maladjustment is observed, manifested by a paradoxical reaction to stimuli in the form of an indirect occlusive effect. When studying the correlations between the indicators of the microvasculature and clinical and instrumental data, it was found that there is a relationship between the linear velocities of the microvasculature and the age, the smoking index, systolic blood pressure, pulse blood pressure. A correlation relationship was established between the FEV1 and the maximum linear systolic velocity along the maximum velocity curve in patients with COPD and COPD and AH. Conclusion: COPD and hypertension are comorbid conditions that lead to more pronounced microcirculatory changes, which can have a mutual effect on the course of these diseases.