CME-1, a novel polysaccharide, suppresses iNOS expression in lipopolysaccharide-stimulated macrophages through ceramide-initiated protein phosphatase 2A activation

Author:

Sheu Joen-Rong12,Chen Zhih-Cherng234,Hsu Ming-Jen1ORCID,Wang Shwu-Huey5,Jung Kuo-Wei2,Wu Wei-Fan2,Pan Szu-Han1,Teng Ruei-Dun1,Yang Chih-Hao1,Hsieh Cheng-Ying1ORCID

Affiliation:

1. Department of Pharmacology; School of Medicine; Taipei Medical University; Taipei Taiwan

2. Graduate Institute of Medical Sciences; School of Medicine; Taipei Medical University; Taipei Taiwan

3. Department of Cardiology; Chi-Mei Medical Center; Tainan City Taiwan

4. Department of Pharmacy; Chia Nan University of Pharmacy & Science; Tainan City Taiwan

5. Core Facility Center; Office of Research and Development; Taipei Medical University; Taipei Taiwan

Funder

National Science Council

Chi-Mei Medical Center-Taipei Medical University

Publisher

Wiley

Subject

Cell Biology,Molecular Medicine

Reference36 articles.

1. TLRs and innate immunity;Beutler;Blood,2009

2. Nitric oxide synthase in innate and adaptive immunity: an update;Bogdan;Trends Immunol,2015

3. Recognition of microorganisms and activation of the immune response;Medzhitov;Nature,2007

4. Structural modifications of bacterial lipopolysaccharide that facilitate gram-negative bacteria evasion of host innate immunity;Matsuura;Front Immunol,2014

5. TLR signaling;Kawai;Cell Death Differ,2006

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