Nanobodies against factor XI apple 3 domain inhibit binding of factor IX and reveal a novel binding site for high molecular weight kininogen

Author:

Bar Barroeta AwitalORCID,Marquart J. ArnoudORCID,Bakhtiari KamranORCID,Meijer Alexander B.ORCID,Urbanus Rolf T.ORCID,Meijers Joost C.M.ORCID

Funder

Landsteiner Foundation for Blood Transfusion Research

Publisher

Elsevier BV

Subject

Hematology

Reference59 articles.

1. Factor XI and contact activation as targets for antithrombotic therapy;Gailani;J Thromb Haemost,2015

2. Factors XI and XII as targets for new anticoagulants;Weitz;Front Med,2017

3. Future prospects for contact factors as therapeutic targets;Gailani;Hematology Am Soc Hematol Educ Program,2014

4. Factor XI as a therapeutic target;Gailani;Arterioscler Thromb Vasc Biol,2016

5. Coagulation factor XI as a novel target for antithrombotic treatment;Löwenberg;J Thromb Haemost,2010

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2. Biology of Factor Xl;Blood Journal;2023-10-24

3. Substrates, Cofactors, and Cellular Targets of Coagulation Factor XIa;Seminars in Thrombosis and Hemostasis;2023-03-20

4. Thrombin activation of the factor XI dimer is a multi-staged process for each subunit;2023-02-11

5. HK is the apple of FXI's eye;Journal of Thrombosis and Haemostasis;2022-11

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