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A ZAP-70 kinase domain variant prevents thymocyte-positive selection despite signalling CD69 induction

  • Published:2014-03-11 Issue:4 Volume:141 Page:587-595
  • ISSN:0019-2805
  • Container-title:Immunology
  • language:en
  • Short-container-title:Immunology

Author:

Siggs Owen M.1,Yates Adèle L.1,Schlenner Susan2,Liston Adrian2,Lesage Sylvie1,Goodnow Christopher C.1

Affiliation:

1. Department of Immunology; John Curtin School of Medical Research; The Australian National University; Canberra ACT Australia

2. Department of Microbiology and Immunology; VIB and Autoimmune Genetics Laboratory; University of Leuven; Leuven Belgium

Publisher

Wiley

Subject

Immunology,Immunology and Allergy

Reference31 articles.

1. Essential role for ZAP-70 in both positive and negative selection of thymocytes;Negishi;Nature,1995

2. A spontaneously arising mutation in the DLAARN motif of murine ZAP-70 abrogates kinase activity and arrests thymocyte development;Wiest;Immunity,1997

3. Differential requirements for ZAP-70 in TCR signaling and T cell development;Kadlecek;J Immunol,1998

4. Defective T cell receptor signaling and CD8+ thymic selection in humans lacking zap-70 kinase;Arpaia;Cell,1994

5. Pre-T cell receptor signals are responsible for the down-regulation of Syk protein tyrosine kinase expression;Chu;J Immunol,1999

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