A novel Zap70 mutation with reduced protein stability demonstrates the rate-limiting threshold for Zap70 in T-cell receptor signalling
Author:
Affiliation:
1. Autoimmune Genetics Laboratory; VIB; Leuven Belgium
2. Department of Microbiology and Immunology; University of Leuven; Leuven Belgium
Funder
FWO
VIB
Publisher
Wiley
Subject
Immunology,Immunology and Allergy
Link
http://onlinelibrary.wiley.com/wol1/doi/10.1111/imm.12199/fullpdf
Reference33 articles.
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2. Evolution and functional impact of rare coding variation from deep sequencing of human exomes;Tennessen;Science,2012
3. ZAP-70: a 70 kd protein-tyrosine kinase that associates with the TCR ζ chain;Chan;Cell,1992
4. ZAP-70: an essential kinase in T-cell signaling;Wang;Cold Spring Harb Perspect Biol,2010
5. Essential role for ZAP-70 in both positive and negative selection of thymocytes;Negishi;Nature,1995
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