Acetylation changes tau interactome to degrade tau in Alzheimer’s disease animal and organoid models-Reference-Cited by-同舟云学术

Acetylation changes tau interactome to degrade tau in Alzheimer’s disease animal and organoid models

Published:2019-11-25 Issue:1 Volume:19 Page:
ISSN:1474-9718
Container-title:Aging Cell
language:en
Short-container-title:Aging Cell

Author:

Choi Heesun¹,Kim Haeng Jun¹,Yang Jinhee¹²,Chae Sehyun³⁴,Lee Wonik¹,Chung Sunwoo¹,Kim Jisoo¹²,Choi Hyunjung⁵,Song Hyeseung⁶,Lee Chang Kon⁶,Jun Jae Hyun²,Lee Yong Jae²,Lee Kyunghyeon⁷,Kim Semi⁷,Sim Hye‐ri⁷,Choi Young Il²,Ryu Keun Ho⁷,Park Jong‐Chan¹,Lee Dongjoon¹,Han Sun‐Ho¹,Hwang Daehee³⁸,Kyung Jangbeen²,Mook‐Jung Inhee¹^ORCID

Affiliation:

1. Department of Biochemistry and Biomedical Sciences College of Medicine Seoul National University Seoul Korea

2. Department of Pharmacology CKD Research Institute CKD Pharmaceutical Company Seoul Korea

3. Center for Plant Aging Research Institute for Basic Science DGIST Daegu Korea

4. Korea Brain Bank Korea Brain Research Institute Daegu Korea

5. Interdisciplinary Graduate Program in Genetic Engineering Seoul National University Seoul Korea

6. Department of Medicinal Chemistry CKD Research Institute CKD Pharmaceutical Company Seoul Korea

7. Department of Nonclinical Development CKD Research Institute CKD Pharmaceutical Company Seoul Korea

8. Department of New Biology DGIST Daegu Korea

Funder

Adolph C. and Mary Sprague Miller Institute for Basic Research in Science, University of California Berkeley

National Research Foundation of Korea

Korea Health Industry Development Institute

Publisher

Wiley

Subject

Cell Biology,Aging

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1111/acel.13081

Reference33 articles.

1. Why do so many clinical trials of therapies for Alzheimer's disease fail?

2. Tau and Aβ imaging, CSF measures, and cognition in Alzheimer’s disease

3. An acetylation–phosphorylation switch that regulates tau aggregation propensity and function

4. Acetylation of the KXGS motifs in tau is a critical determinant in modulation of tau aggregation and clearance

5. Alzheimer's disease drug development pipeline: 2017

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