BBIT20 inhibits homologous DNA repair with disruption of the BRCA1–BARD1 interaction in breast and ovarian cancer

Author:

Raimundo Liliana1,Paterna Angela2,Calheiros Juliana1ORCID,Ribeiro Joana2,Cardoso David S. P.2,Piga Ilaria34,Neto Susana Junqueira567,Hegan Denise89,Glazer Peter M.89,Indraccolo Stefano34,Mulhovo Silva10,Costa José Luís567,Ferreira Maria‐José U.2ORCID,Saraiva Lucília1ORCID

Affiliation:

1. LAQV/REQUIMTE, Department of Biological Sciences, Laboratory of Microbiology, Faculty of Pharmacy University of Porto Rua de Jorge Viterbo Ferreira 228 Porto 4050‐313 Portugal

2. Research Institute for Medicines (iMed.ULisboa), Faculty of Pharmacy Universidade de Lisboa Av. Prof. Gama Pinto Lisbon 1649‐003 Portugal

3. Immunology and Molecular Oncology Unit Veneto Institute of Oncology IOV, IRCCS Padova Italy

4. Department of Surgery, Oncology and Gastroenterology University of Padova Padova 35128 Italy

5. Institute of Molecular Pathology and Immunology University of Porto (IPATIMUP) Porto 4200‐135 Portugal

6. Institute for Research and Innovation in Health (i3S) University of Porto Rua Alfredo Allen Porto 4200‐135 Portugal

7. Faculty of Medicine University of Porto Praça de Gomes Teixeira Porto 4099‐002 Portugal

8. Department of Therapeutic Radiology Yale University School of Medicine New Haven Connecticut CT06511 USA

9. Department of Genetics Yale University School of Medicine New Haven Connecticut CT06511 USA

10. Centro de Estudos Moçambicanos e de Etnociências (CEMEC), Faculty of Natural Sciences and Mathematics Pedagogical University Maputo 21402161 Mozambique

Funder

Fundació Catalana de Trasplantament

Publisher

Wiley

Subject

Pharmacology

Reference57 articles.

1. DNA repair in cancer: Emerging targets for personalized therapy;Abbotts R.;Cancer Management and Research,2014

2. The concise guide to pharmacology 2019/20: Enzymes;Alexander S. P. H.;British Journal of Pharmacology,2019

3. The Concise Guide To Pharmacology 2019/20: Introduction and other protein targets;Alexander S. P. H.;British Journal of Pharmacology,2019

4. Discovery of a small-molecule protein kinase Cδ-selective activator with promising application in colon cancer therapy

5. Combined drug therapeutic strategies for the effective treatment of Triple Negative Breast Cancer

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