CD33M inhibits microglial phagocytosis, migration and proliferation, but the Alzheimer’s disease‐protective variant CD33m stimulates phagocytosis and proliferation, and inhibits adhesion-Reference-Cited by-同舟云学术

CD33M inhibits microglial phagocytosis, migration and proliferation, but the Alzheimer’s disease‐protective variant CD33m stimulates phagocytosis and proliferation, and inhibits adhesion

Published:2021-04-05 Issue:2 Volume:158 Page:297-310
ISSN:0022-3042
Container-title:Journal of Neurochemistry
language:en
Short-container-title:J. Neurochem.

Author:

Butler Claire Ann¹²^ORCID,Thornton Peter²,Brown Guy Charles¹^ORCID

Affiliation:

1. Department of Biochemistry University of Cambridge Cambridge UK

2. AstraZeneca Cambridge UK

Funder

Biotechnology and Biological Sciences Research Council

Medical Research Council

Publisher

Wiley

Subject

Cellular and Molecular Neuroscience,Biochemistry

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1111/jnc.15349

Reference44 articles.

1. Activated microglia desialylate their surface, stimulating complement receptor 3‐mediated phagocytosis of neurons

2. The inhibitory effect of anti-CD33 monoclonal antibodies on AML cell growth correlates with Syk and/or ZAP-70 expression

3. Repression of phagocytosis by human CD33 is not conserved with mouse CD33;Bhattacherjee A.;Communications Biology,2019

4. CD33 Alzheimer's disease locus: altered monocyte function and amyloid biology

5. CD33/Siglec-3 Binding Specificity, Expression Pattern, and Consequences of Gene Deletion in Mice

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