Simvastatin does not influence the intestinal P-glycoprotein and MPR2, and the disposition of talinolol after chronic medication in healthy subjects genotyped for the ABCB1, ABCC2 and SLCO1B1 polymorphisms

Author:

Bernsdorf Annika,Giessmann Thomas,Modess Christiane,Wegner Danilo,Igelbrink Stefanie,Hecker Ute,Haenisch Sierk,Cascorbi Ingolf,Terhaag Bernd,Siegmund Werner

Publisher

Wiley

Subject

Pharmacology (medical),Pharmacology

Reference38 articles.

1. Disposition and bioavailability of the beta 1-adrenoceptor antagonist talinolol in man;Trausch;Biopharm Drug Dispos,1995

2. Evidence for intestinal secretion as an additional clearance pathway of talinolol enantiomers. concentration- and dose-dependent absorption in vitro and in vivo;Wetterich;Pharm Res,1996

3. Talinolol-verapamil interaction is not solely due to p-glycoprotein inhibition;Schwarz;Clin Pharmacol Ther,2001

4. P-glycoprotein transporters and the gastrointestinal tract: evaluation of the potential in vivo relevance of in vitro data employing talinolol as model compound;Spahn-Langguth;Int J Clin Pharmacol Ther,1998

5. Direct demonstration of small intestinal secretion and site-dependent absorption of the beta-blocker talinolol in humans;Gramatte;Clin Pharmacol Ther,1996

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