Tetrandrine, a plant alkaloid, inhibits the production of tumour necrosis factor-alpha (cachectin) hy human monocytes-Reference-Cited by-同舟云学术

Tetrandrine, a plant alkaloid, inhibits the production of tumour necrosis factor-alpha (cachectin) hy human monocytes

Published:1990-05 Issue:2 Volume:80 Page:232-235
ISSN:1365-2249
Container-title:Clinical and Experimental Immunology
language:en
Short-container-title:

Author:

FERRANTE A¹,SEOW W K²,ROWAN-KELLY B¹,THONG Y H²

Affiliation:

1. Department of Immunology and University Department of Paediatrics, Adelaide Children's Hospital. Adelaide, Australia

2. lmmunobiology Laboratory, Department of Child Health, University of Queensland, Mater Children's Hospital, South Brisbane, Australia

Abstract

SUMMARY Human mononuclcar leucocytes (MNL) or the adherent fraction (monocytes) produced tumour necrosis factor-alpha (TNF-α) (by EL1SA) in culture when stimulated with killed Staphylococcus aureus. The bisbenzylisoquinoline alkaloid, tetrandrine inhibited the capacity of MNL and monocytes to produce TNF-α at a concentration range of 0·1 to 5 μg/ml. Tetrandrine may be potentially useful in the treatment of inflammatory diseases in which TNF-α plays a major role.

Publisher

Oxford University Press (OUP)

Subject

Immunology,Immunology and Allergy

Link

https://academic.oup.com/cei/article-pdf/80/2/232/42218378/j.1365-2249.1990.tb05239.x.pdf

Reference27 articles.

1. An examination of the cytotoxic effects of silica on macrophagcs;Allison;J. exp. Med,1966

2. A study of macrophage-mediated initiation of fibrosis by asbestos and silica using a diffusion chamber technique;Bateman;Br. J. exp. Pathol,1982

3. The role of cell injury and the continuing inflammatory response in the generation of silicotic pulmonary fibrosis;Bowden;J. pathol,1984

4. Independent regulation of tumor necrosis factor and lymphotoxin production by human peripheral blood lymphocytes;Cuturi;J. exp. Med,1987

5. IgG subclass assays with polyclonal antisera and monoclonal antibodies;Ferrante;Monogr. Allergy,1988

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