Inhibition of two-pore channels in antigen-presenting cells promotes the expansion of TNFR2-expressing CD4 + Foxp3 + regulatory T cells-Reference-Cited by-同舟云学术

Inhibition of two-pore channels in antigen-presenting cells promotes the expansion of TNFR2-expressing CD4 + Foxp3 + regulatory T cells

Published:2020-10-02 Issue:40 Volume:6 Page:
ISSN:2375-2548
Container-title:Science Advances
language:en
Short-container-title:Sci. Adv.

Author:

He Tianzhen¹^ORCID,Yang De²^ORCID,Li Xiao-Qing²³^ORCID,Jiang Mengmeng¹^ORCID,Islam Md Sahidul¹,Chen Shaokui¹,Chen Yibo¹,Yang Yang¹,Chou Chon-Kit¹,Trivett Anna L.²^ORCID,Oppenheim Joost J.²^ORCID,Chen Xin¹^ORCID

Affiliation:

1. State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macau SAR 999078, China.

2. Cancer and Inflammation Program, Center for Cancer Research, National Cancer Institute at Frederick, NIH, Frederick, MD, USA.

3. Department of Biochemistry and Molecular Biology, Tianjin Medical University Cancer Institute and Hospital, Tianjin 300060, China.

Abstract

Inhibition of TPCs up-regulates tmTNF expression on APCs by disrupting mTACE expression and promotes expansion of TNFR2 + Tregs.

Funder

University of Macau

The Science and Technology Development Fund, Macau SAR

Frederick, NCI/NIH, USA

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference39 articles.

1. Regulatory T Cells and Immune Tolerance

2. TNF biology, pathogenic mechanisms and emerging therapeutic strategies

3. Interaction of TNF with TNF Receptor Type 2 Promotes Expansion and Function of Mouse CD4+CD25+ T Regulatory Cells

4. Exogenous TNFR2 activation protects from acute GvHD via host T reg cell expansion

5. TNF receptor 2 signaling prevents DNA methylation at the Foxp3 promoter and prevents pathogenic conversion of regulatory T cells

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