Effects of atomoxetine on the QT interval in healthy CYP2D6 poor metabolizers

Author:

Loghin Corina1,Haber Harry2,Beasley Charles M.1,Kothare Prajakti A.,Kauffman Lynnette,April John1,Jin Ling1,Allen Albert J.1,Mitchell Malcolm I.1

Affiliation:

1. Eli Lilly and Company; Indianapolis; IN; 46285; USA

2. Department of Statistics; Pharmanet/i3, Inc.; Ann Arbor; MI; USA

Publisher

Wiley

Subject

Pharmacology (medical),Pharmacology

Reference30 articles.

1. ICH Guidance for industry E14 clinical evaluation of QT/QTc interval prolongation and proarrhythmic potential for non-antiarrhythmic drugs http://www.fda.gov/downloads/RegulatoryInformation/Guidances/ucm129357.pdf

2. Selective noradrenaline reuptake inhibitor atomoxetine directly blocks hERG currents;Scherer;Br J Pharmacol,2009

3. Investigating dynamic protocol-dependence of hERG potassium channel inhibition at 37 degrees C: cisapride versus dofetilide;Milnes;J Pharmacol Toxicol Methods,2010

4. Clinical pharmacokinetics of atomoxetine;Sauer;Clin Pharmacokinet,2005

5. Atomoxetine: a review of its use in adults with attention deficit hyperactivity disorder;Simpson;Drugs,2004

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