Effects of atomoxetine on the QT interval in healthy CYP2D6 poor metabolizers
Author:
Affiliation:
1. Eli Lilly and Company; Indianapolis; IN; 46285; USA
2. Department of Statistics; Pharmanet/i3, Inc.; Ann Arbor; MI; USA
Publisher
Wiley
Subject
Pharmacology (medical),Pharmacology
Link
http://onlinelibrary.wiley.com/wol1/doi/10.1111/j.1365-2125.2012.04382.x/fullpdf
Reference30 articles.
1. ICH Guidance for industry E14 clinical evaluation of QT/QTc interval prolongation and proarrhythmic potential for non-antiarrhythmic drugs http://www.fda.gov/downloads/RegulatoryInformation/Guidances/ucm129357.pdf
2. Selective noradrenaline reuptake inhibitor atomoxetine directly blocks hERG currents;Scherer;Br J Pharmacol,2009
3. Investigating dynamic protocol-dependence of hERG potassium channel inhibition at 37 degrees C: cisapride versus dofetilide;Milnes;J Pharmacol Toxicol Methods,2010
4. Clinical pharmacokinetics of atomoxetine;Sauer;Clin Pharmacokinet,2005
5. Atomoxetine: a review of its use in adults with attention deficit hyperactivity disorder;Simpson;Drugs,2004
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