Alantolactone induces apoptosis in THP‐1 cells through STAT3, survivin inhibition, and intrinsic apoptosis pathway

Author:

Ahmad Bashir1ORCID,Gamallat Yaser12,Su Pengyu1,Husain Akbar1,Rehman Ata Ur1,Zaky Mohamed Y.1,Bakheet Ahmed Musa Hago3,Tahir Naeem1,Xin Yi1,Liang Wang4

Affiliation:

1. College of Basic Medical Sciences Dalian Medical University Dalian China

2. Guangzhou Institute of Pediatrics Guangzhou Women and Childrens Medical Center Guangzhou China

3. The Third Affiliated Hospital of Sun‐yat Sen University Guangzhou China

4. Stem Cell Clinical Research Center National Joint Engineering Laboratory Regenerative Medicine Center The First Affiliated Hospital of Dalian Medical Dalian City China

Funder

National Natural Science Foundation of China

Publisher

Wiley

Subject

Molecular Medicine,Biochemistry,Drug Discovery,Pharmacology,Organic Chemistry

Reference30 articles.

1.

Natural gypenosides: targeting cancer through different molecular pathways

2. Alantolactone sensitizes H1650 lung adenocarcinoma cells to gefitinib via inhibition of STAT3 activation;Ahmad B.;BioCell,2019

3. Alantolactone enhances Cisplatin anticancer activity in A549 cells through inhibition of STAT3 activation and mitochondrial dependent pathway;Ahmad B.;BioCell,2020

4. Discovery and resupply of pharmacologically active plant-derived natural products: A review

5. The human leukemia cell line, THP-1: A multifacetted model for the study of monocyte-macrophage differentiation

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