Research progress on antitumor mechanisms and molecular targets of Inula sesquiterpene lactones

Author:

Cao Fei,Chu Chu,Qin Jiang-Jiang,Guan XiaoqingORCID

Abstract

AbstractThe pharmacological effects of natural product therapy have received sigificant attention, among which terpenoids such as sesquiterpene lactones stand out due to their biological activity and pharmacological potential as anti-tumor drugs. Inula sesquiterpene lactones are a kind of sesquiterpene lactones extracted from Inula species. They have many pharmacological activities such as anti-inflammation, anti-asthma, anti-tumor, neuroprotective and anti-allergic. In recent years, more and more studies have proved that they are important candidate drugs for the treatment of a variety of cancers because of its good anti-tumor activity. In this paper, the structure, structure–activity relationship, antitumor activities, mechanisms and targets of Inula sesquiterpene lactones reported in recent years were reviewed in order to provide clues for the development of novel anticancer drugs. Graphical abstract

Funder

Traditional Chinese Medicine Science and Technology Program of Zhejiang Province

National Key R and D Program of China

Program of Zhejiang Provincial TCM Sci-tech Plan

Publisher

Springer Science and Business Media LLC

Subject

Complementary and alternative medicine,Pharmacology

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