Therapeutic potential of nitric oxide in vascular aging due to the promotion of angiogenesis-Reference-Cited by-同舟云学术

Therapeutic potential of nitric oxide in vascular aging due to the promotion of angiogenesis

Published:2023-04-16 Issue:2 Volume:102 Page:395-407
ISSN:1747-0277
Container-title:Chemical Biology & Drug Design
language:en
Short-container-title:Chem Biol Drug Des

Author:

Zhang Jiaming¹,Li Cunrui¹,Zhang Yihua¹,Wu Jianbing¹,Huang Zhangjian¹²

Affiliation:

1. State Key Laboratory of Natural Medicines, Jiangsu Key Laboratory of Drug Discovery for Metabolic Diseases, Center of Drug Discovery China Pharmaceutical University Nanjing China

2. School of Pharmacy Xinjiang Medical University China

Abstract

AbstractThe decrease in angiogenesis that occurs with aging significantly contributes to the higher incidence and mortality of cardiovascular diseases among the elderly. This decline in angiogenesis becomes more pronounced with increasing age and is closely linked to abnormal function and senescence of endothelial cells. Enhancing angiogenesis in aging and targeting senescent endothelial cells have gained considerable attention. Nitric oxide (NO) has been thoroughly investigated for its function in regulating angiogenesis and is an important factor that can counteract endothelial cell senescence. This review summarizes the mechanisms of reduced angiogenesis during aging and therapeutic strategies targeting senescent cells. We also discuss the potential of combining the current approaches with NO in promoting angiogenesis in aging vessels.

Funder

National Natural Science Foundation of China

Publisher

Wiley

Subject

Molecular Medicine,Biochemistry,Drug Discovery,Pharmacology,Organic Chemistry

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1111/cbdd.14248

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