Rat brain CYP2D activity alters in vivo central oxycodone metabolism, levels and resulting analgesia-Reference-Cited by-同舟云学术

Rat brain CYP2D activity alters in vivo central oxycodone metabolism, levels and resulting analgesia

Published:2017-12-21 Issue:2 Volume:24 Page:228-238
ISSN:1355-6215
Container-title:Addiction Biology
language:en
Short-container-title:Addiction Biology

Author:

McMillan Douglas M.¹,Miksys Sharon¹,Tyndale Rachel F.¹²^ORCID

Affiliation:

1. Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health (CAMH) and Department of Pharmacology and Toxicology; University of Toronto; Canada

2. Department of Psychiatry; University of Toronto; Canada

Funder

Canada Research Chairs in Pharmacogenomics

Canadian Institutes of Health Research

Campbell Family Mental Health Research Institute

Ontario Ministry of Research, Innovation and Science

Canada Foundation for Innovation

CAMH Foundation

Publisher

Wiley

Subject

Psychiatry and Mental health,Pharmacology,Medicine (miscellaneous)

Link

http://onlinelibrary.wiley.com/wol1/doi/10.1111/adb.12590/fullpdf

Reference49 articles.

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3. Nicotine addiction;Benowitz;Prim Care,1999

4. Oxycodone pharmacokinetics and pharmacodynamics in the rat in the presence of the P-glycoprotein inhibitor PSC833;Bostrom;J Pharm Sci,2005

5. In vivo blood-brain barrier transport of oxycodone in the rat: indications for active influx and implications for pharmacokinetics/pharmacodynamics;Bostrom;Drug Metab Dispos,2006

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3. CYP2D in the brain impacts oral hydrocodone analgesia in vivo;Neuropharmacology;2022-12

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