Sex, estrous cycle, and hormone regulation of CYP2D in the brain alters oxycodone metabolism and analgesia

Author:

Arguelles Nicole,Richards JanielleORCID,El-Sherbeni Ahmed A.,Miksys Sharon,Tyndale Rachel F.

Funder

Canadian Institutes of Health Research

National Institutes of Health

Canada Research Chairs

Centre for Addiction and Mental Health

Centre for Addiction and Mental Health Foundation

Publisher

Elsevier BV

Subject

Pharmacology,Biochemistry

Reference35 articles.

1. Impact of the CYP2D6 genotype on post-operative intravenous oxycodone analgesia;Zwisler;Acta Anaesthesiol Scand,2010

2. Induction of the drug metabolizing enzyme CYP2D in monkey brain by chronic nicotine treatment;Mann;Neuropharmacology,2008

3. Nicotine Increases Codeine Analgesia Through the Induction of Brain CYP2D and Central Activation of Codeine to Morphine;McMillan;Neuropsychopharmacology,2015

4. Chronic nicotine treatment induces rat CYP2D in the brain but not in the liver: an investigation of induction and time course;Yue;J. Psychiatry Neurosci.,2008

5. Measurement of CYP2D6 and CYP3A4 activity in vivo with dextromethorphan: sources of variability and predictors of adverse effects in 419 healthy subjects;Funck-Brentano;Eur. J. Clin. Pharmacol.,2005

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