How pyridoxal 5′-phosphate differentially regulates human cytosolic and mitochondrial serine hydroxymethyltransferase oligomeric state

Author:

Giardina Giorgio1,Brunotti Paolo1,Fiascarelli Alessio1,Cicalini Alessandra1,Costa Mauricio G. S.2,Buckle Ashley M.3,di Salvo Martino L.1,Giorgi Alessandra1,Marani Marina1,Paone Alessio1,Rinaldo Serena1,Paiardini Alessandro1,Contestabile Roberto1,Cutruzzolà Francesca1

Affiliation:

1. Dipartimento di Scienze Biochimiche ‘A. Rossi Fanelli’; Sapienza Università di Roma; Italy

2. Programa de Computação Científica; Fundação Oswaldo Cruz; Rio de Janeiro Brazil

3. Department of Biochemistry and Molecular Biology; School of Biomedical Sciences; Faculty of Medicine; Monash University; Clayton Vic. Australia

Funder

Sapienza University of Rome

Associazione Italiana Ricerca sul Cancro

European Community's Seventh Framework Programme Biostruct-X

Fondazione Italiana Ricerca sul Cancro

Publisher

Wiley

Subject

Cell Biology,Molecular Biology,Biochemistry

Reference68 articles.

1. Serine and glycine metabolism in cancer;Amelio;Trends Biochem Sci,2014

2. Metabolite profiling identifies a key role for glycine in rapid cancer cell proliferation;Jain;Science,2012

3. Serine, but not glycine, supports one-carbon metabolism and proliferation of cancer cells;Labuschagne;Cell Rep,2014

4. Serine hydroxymethyltransferase: a model enzyme for mechanistic, structural, and evolutionary studies;Florio;Biochim Biophys Acta,2011

5. Folate deprivation reduces homocysteine remethylation in a human intestinal epithelial cell culture model: role of serine in one-carbon donation;Townsend;Am J Physiol,2004

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