Image‐based deep learning reveals the responses of human motor neurons to stress and VCP ‐related ALS-Reference-Cited by-同舟云学术

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Image‐based deep learning reveals the responses of human motor neurons to stress and VCP ‐related ALS

Published:2021-10-18 Issue:2 Volume:48 Page:
ISSN:0305-1846
Container-title:Neuropathology and Applied Neurobiology
language:en
Short-container-title:Neuropathology Appl Neurobio

Author:

Verzat Colombine¹^ORCID,Harley Jasmine²³,Patani Rickie²³^ORCID,Luisier Raphaëlle¹^ORCID

Affiliation:

1. Genomics and Health Informatics Group Idiap Research Institute Martigny Switzerland

2. Human Stem Cells and Neurodegeneration Laboratory The Francis Crick Institute London UK

3. Department of Neuromuscular Diseases UCL Queen Square Institute of Neurology London UK

Funder

Wellcome Trust

Medical Research Council Canada

Cancer Research UK

Francis Crick Institute

Publisher

Wiley

Subject

Physiology (medical),Neurology (clinical),Neurology,Histology,Pathology and Forensic Medicine

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1111/nan.12770

Reference66 articles.

1. Ubiquitinated TDP-43 in Frontotemporal Lobar Degeneration and Amyotrophic Lateral Sclerosis

2. Intron retention and nuclear loss of SFPQ are molecular hallmarks of ALS

3. Widespread FUS mislocalization is a molecular hallmark of amyotrophic lateral sclerosis

4. HoganAL GrimaN FifitaJA et al.SFPQ intron retention reduced expression and aggregate formation in central nervous system tissue are pathological features of amyotrophic lateral sclerosis.Cold Spring Harbor Laboratory.2020; 2020.09.22.309062 doi:https://doi.org/10.1101/2020.09.22.309062.

5. Stress granules as crucibles of ALS pathogenesis

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1. The use of artificial intelligence in induced pluripotent stem cell-based technology over 10-year period: A systematic scoping review;PLOS ONE;2024-05-21

2. Deep Learning Analysis on Images of iPSC-derived Motor Neurons Carrying fALS-genetics Reveals Disease-Relevant Phenotypes;2024-01-05

3. Classification of iPSC-Derived Cultures Using Convolutional Neural Networks to Identify Single Differentiated Neurons for Isolation or Measurement;2023-12-25

4. Stress granule assembly in vivo is deficient in the CNS of mutant TDP-43 ALS mice;Human Molecular Genetics;2022-08-22

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