Deciphering the mechanism of potent peptidomimetic inhibitors targeting plasmepsins – biochemical and structural insights

Author:

Mishra Vandana1,Rathore Ishan1,Arekar Anagha1,Sthanam Lakshmi Kavitha1,Xiao Huogen2,Kiso Yoshiaki3,Sen Shamik1,Patankar Swati1,Gustchina Alla4,Hidaka Koushi5,Wlodawer Alexander4,Yada Rickey Y.6,Bhaumik Prasenjit1

Affiliation:

1. Department of Biosciences and Bioengineering Indian Institute of Technology Bombay Powai, Mumbai India

2. Department of Molecular and Cellular Biology University of Guelph ONCanada

3. Laboratory of Peptide Sciences Nagahama Institute of Bio‐Science and Technology Japan

4. Protein Structure Section Macromolecular Crystallography Laboratory National Cancer Institute Frederick MD USA

5. Division of Pharmaceutical Chemistry Faculty of Pharmaceutical Sciences Kobe Gakuin University Japan

6. Faculty of Land and Food Systems University of British Columbia Vancouver BC Canada

Funder

Department of Biotechnology , Ministry of Science and Technology

Indian Institute of Technology Bombay

National Cancer Institute

Takeda Science Foundation

Natural Sciences and Engineering Research Council of Canada

Publisher

Wiley

Subject

Cell Biology,Molecular Biology,Biochemistry

Reference63 articles.

1. Malaria

2. WHO (World Health Organisation)(2016)World malaria report 2016.

3. The threat of antimalarial drug resistance

4. Antimalarial drugs: modes of action and mechanisms of parasite resistance

5. Studies on malarial parasites; chemical and metabolic changes during growth and multiplication in vivo and in vitro;Ball EG;J Biol Chem,1948

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