The effects of graded levels of calorie restriction: IX. Global metabolomic screen reveals modulation of carnitines, sphingolipids and bile acids in the liver of C57BL/6 mice

Author:

Green Cara L.1,Mitchell Sharon E.1,Derous Davina1,Wang Yingchun2,Chen Luonan3,Han Jing-Dong J.4,Promislow Daniel E. L.5,Lusseau David1,Douglas Alex1,Speakman John R.12

Affiliation:

1. Institute of Biological and Environmental Sciences; University of Aberdeen; Aberdeen UK

2. State Key Laboratory of Molecular Developmental Biology; Institute of Genetics and Developmental Biology; Chinese Academy of Sciences; Chaoyang Beijing China

3. Key Laboratory of Systems Biology, Innovation Center for Cell Signaling Network; Institute of Biochemistry and Cell Biology; Shanghai Institute of Biological Sciences; Chinese Academy of Sciences; Shanghai China

4. Key Laboratory of Computational Biology; Chinese Academy of Sciences-Max Planck Partner Institute for Computational Biology; Shanghai Institutes for Biological Sciences; Chinese Academy of Sciences; Shanghai China

5. Department of Pathology and Department of Biology; University of Washington; Seattle WA USA

Funder

Biotechnology and Biological Sciences Research Council

National Institutes of Health

Publisher

Wiley

Subject

Cell Biology,Aging

Reference88 articles.

1. Long-term food restriction prevents aging-associated sphingolipid turnover dysregulation in the brain;Babenko;Arch. Gerontol. Geriatr.,2014

2. Controlling the false discovery rate: a practical and powerful approach to multiple testing;Benjamini;J. Roy. Statist. Soc. Ser. B (Methodological),1995

3. Age-related changes in bile acid synthesis and hepatic nuclear receptor expression;Bertolotti;Eur. J. Clin. Invest.,2007

4. Dietary L-carnitine supplementation in obese cats alters carnitine metabolism and decreases ketosis during fasting and induced hepatic lipidosis;Blanchard;J. Nutr.,2002

5. Model selection and Akaike's Information Criterion (AIC): The general theory and its analytical extensions;Bozdogan;Psychometrika,1987

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