Harmful somatic mutations: lessons from the dark side
Author:
Publisher
Wiley
Subject
Immunology,Immunology and Allergy
Link
http://onlinelibrary.wiley.com/wol1/doi/10.1111/j.1600-065X.1998.tb01442.x/fullpdf
Reference108 articles.
1. Generation and analysis of random point mutations in an antibody CDR2 sequence: many mutated antibodies lose their ability to bind antigen.
2. Enhancement and destruction of antibody function by somatic mutation: unequal occurrence is controlled by V gene combinatorial associations.
3. Defective secretion of an immunoglobulin caused by mutations in the heavy chain complementarity determining region 2.
4. Structure and function of anti-DNA autoantibodies derived from a single autoimmune mouse.
Cited by 23 articles. 订阅此论文施引文献 订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献
1. Single amino acid substitution in LC-CDR1 induces Russell body phenotype that attenuates cellular protein synthesis through eIF2α phosphorylation and thereby downregulates IgG secretion despite operational secretory pathway traffic;mAbs;2017-04-05
2. Computationally driven antibody engineering enables simultaneous humanization and thermostabilization;Protein Engineering Design and Selection;2016-06-21
3. Application of Antibody Engineering in the Development of Next Generation Antibody-Based Therapeutics;Development of Antibody-Based Therapeutics;2012
4. Leveraging SBDD in Protein Therapeutic Development: Antibody Engineering;Methods in Molecular Biology;2011-12-07
5. Coevolution of Antibody Stability and Vκ CDR-L3 Canonical Structure;Journal of Molecular Biology;2010-10
1.学者识别学者识别
2.学术分析学术分析
3.人才评估人才评估
"同舟云学术"是以全球学者为主线，采集、加工和组织学术论文而形成的新型学术文献查询和分析系统，可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容，当前同舟云学术共收录了国内外主流学术期刊6万余种，收集的期刊论文及会议论文总量共计约1.5亿篇，并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询！咨询电话：010-8811{复制后删除}0370
www.globalauthorid.com
TOP
Copyright © 2019-2024 北京同舟云网络信息技术有限公司 京公网安备11010802033243号 京ICP备18003416号-3