Single amino acid substitution in LC-CDR1 induces Russell body phenotype that attenuates cellular protein synthesis through eIF2α phosphorylation and thereby downregulates IgG secretion despite operational secretory pathway traffic-Reference-Cited by-同舟云学术

Single amino acid substitution in LC-CDR1 induces Russell body phenotype that attenuates cellular protein synthesis through eIF2α phosphorylation and thereby downregulates IgG secretion despite operational secretory pathway traffic

Published:2017-04-05 Issue:5 Volume:9 Page:854-873
ISSN:1942-0862
Container-title:mAbs
language:en
Short-container-title:mAbs

Author:

Hasegawa Haruki¹^ORCID,Hsu Ann²,Tinberg Christine E.¹^ORCID,Siegler Karen E.³,Nazarian Aaron A.²^ORCID,Tsai Mei-Mei²^ORCID

Affiliation:

1. Department of Therapeutic Discovery, Amgen Inc., South San Francisco, CA, USA

2. Department of Therapeutic Discovery, Amgen Inc., Thousand Oaks, CA, USA

3. Department of Cardiometabolic Disorders, Amgen Inc., South San Francisco, CA, USA

Publisher

Informa UK Limited

Subject

Immunology,Immunology and Allergy

Link

https://www.tandfonline.com/doi/pdf/10.1080/19420862.2017.1314875

Reference46 articles.

1. Somatic generation of antibody diversity

2. The Role of Somatic Hypermutation in the Generation of Antibody Diversity

3. Enhancement and destruction of antibody function by somatic mutation: unequal occurrence is controlled by V gene combinatorial associations.

4. Harmful somatic mutations: lessons from the dark side

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