[18F]JNJ42259152 binding to phosphodiesterase 10A, a key regulator of medium spiny neuron excitability, is altered in the presence of cyclic AMP
Author:
Affiliation:
1. Laboratory for Radiopharmacy; Department of Pharmaceutical and Pharmacological Sciences KU Leuven; Leuven Belgium
2. Division of Nuclear Medicine; KU Leuven and University Hospital Leuven; Leuven Belgium
Funder
KU Leuven
Fonds Wetenschappelijk Onderzoek
Publisher
Wiley
Subject
Cellular and Molecular Neuroscience,Biochemistry
Link
http://onlinelibrary.wiley.com/wol1/doi/10.1111/jnc.13855/fullpdf
Reference45 articles.
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3. Alterations of cAMP response element-binding activity in the aged rat brain in response to administration of rolipram, a cAMP-specific phosphodiesterase inhibitor;Asanuma;Brain Res. Mol. Brain Res.,1996
4. Stimulation of adenosine 3′,5′-monophosphate hydrolysis by guanosine 3′,5′-monophosphate;Beavo;J. Biol. Chem.,1971
5. Preclinical evaluation of [(18)F]JNJ42259152 as a PET tracer for PDE10A;Celen;NeuroImage,2013
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