Synthesis, In Vivo Occupancy, and Radiolabeling of Potent Phosphodiesterase Subtype-10 Inhibitors as Candidates for Positron Emission Tomography Imaging-Reference-Cited by-同舟云学术

Synthesis, In Vivo Occupancy, and Radiolabeling of Potent Phosphodiesterase Subtype-10 Inhibitors as Candidates for Positron Emission Tomography Imaging

Published:2011-08-02 Issue:16 Volume:54 Page:5820-5835
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Andrés José-Ignacio¹,De Angelis Meri¹,Alcázar Jesús¹,Iturrino Laura¹,Langlois Xavier²,Dedeurwaerdere Stefanie²,Lenaerts Ilse²,Vanhoof Greet²,Celen Sofie³,Bormans Guy³

Affiliation:

1. Medicinal Chemistry, Janssen Research & Development, Janssen-Cilag SA, C/Jarama 75, 45007 Toledo, Spain

2. Neuroscience, Janssen Research & Development, Janssen Pharmaceutica NV, Turnhoutseweg 30, B-2340 Beerse, Belgium

3. Laboratory for Radiopharmacy and IMIR, Faculty of Pharmaceutical Sciences, KU Leuven, Herestraat 49, B-3000 Leuven, Belgium

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm200536d

Reference28 articles.

1. Biochemistry and Physiology of Cyclic Nucleotide Phosphodiesterases: Essential Components in Cyclic Nucleotide Signaling