Two pregnant women with immune‐mediated thrombotic thrombocytopenic purpura: A case report

Author:

Uchida Akiko1,Tanimura Kenji1ORCID,Sasagawa Yuki1,Yamada Hirotaka2,Katayama Yoshio3,Matsumoto Masanori4

Affiliation:

1. Department of Obstetrics and Gynecology Kobe University Graduate School of Medicine Kobe Japan

2. Department of Rheumatology and Clinical Immunology Kobe University Graduate School of Medicine Kobe Japan

3. Division of Hematology, Department of Medicine Kobe University Graduate School of Medicine Kobe Japan

4. Department of Blood Transfusion Medicine Nara Medical University Kashihara Japan

Abstract

AbstractThrombotic thrombocytopenic purpura (TTP) during pregnancy is life‐threatening. We encountered two pregnant women with immune‐mediated TTP (iTTP). A 40‐year‐old primigravida woman was referred at 19 gestational weeks (GWs) owing to iTTP. She received plasma exchange (PE) and steroid therapies and delivered a live infant at 27 GWs by cesarean delivery. A 29‐year‐old primigravida woman was referred owing to intrauterine fetal death and thrombocytopenia at 20 GWs. She was diagnosed with iTTP and received PE therapy. She required additional PE and steroid therapies owing to relapse. Before her second pregnancy, she received prednisolone and hydroxychloroquine according to the therapy for systemic lupus erythematosus (SLE). She had induced labor at 37 GWs owing to decrease plasma level of a disintegrin‐like and metalloproteinase with thrombospondin type 1 motif 13 (ADAMTS13) activity. Close monitoring of plasma ADAMTS13 activity level and treatments for underlying SLE may prevent iTTP relapse and lead to a good prognosis.

Publisher

Wiley

Subject

Obstetrics and Gynecology

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3