Thrombotic thrombocytopenic purpura and pregnancy: presentation, management, and subsequent pregnancy outcomes

Author:

Scully Marie1,Thomas Mari2,Underwood Mary2,Watson Henry3,Langley Katherine2,Camilleri Raymond S.4,Clark Amanda5,Creagh Desmond6,Rayment Rachel7,Mcdonald Vickie8,Roy Ashok9,Evans Gillian10,McGuckin Siobhan1,Ni Ainle Fionnuala11,Maclean Rhona12,Lester William13,Nash Michael14,Scott Rosemary1,O Brien Patrick1,

Affiliation:

1. University College London Hospitals, London, United Kingdom;

2. University College London, London, United Kingdom;

3. Aberdeen Royal Infirmary, Aberdeen, United Kingdom;

4. University of Westminster, London, United Kingdom;

5. University Hospitals Bristol National Health Service Foundation Trust, Bristol, United Kingdom;

6. Royal Cornwall Hospital Trust, Cornwall, United Kingdom;

7. Cardiff and Vale University Hospital, Cardiff, United Kingdom;

8. Guy’s and St. Thomas’ National Health Service Foundation Trust, London, United Kingdom;

9. Basingstoke and North Hampshire National Health Service Trusts, Basingstoke, Hampshire, United Kingdom;

10. Kent and Canterbury Hospitals, Canterbury, Kent, United Kingdom;

11. The Rotunda Hospital, Dublin, Ireland;

12. Sheffield Teaching Hospital National Health Service Trust, Sheffield, United Kingdom;

13. University Hospital Birmingham, Birmingham, United Kingdom; and

14. Manchester Royal Infirmary, Manchester, United Kingdom

Abstract

Key Points In women presenting with an initial diagnosis of TTP during pregnancy, cTTP was more common than acquired TTP. Active monitoring and management during pregnancy results in positive pregnancy outcomes.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

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